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Alternative library for image_slicer

I'm working with large tiff images (~~16k x 16k). I used slicing image for 9 tiles in my algorithm (library: image_slicer) before image processing.

I'm looking for some faster alternative method of slicing image for tiles. This one is so slow - when i open 4-5 images in once time, algorith slicing images for few minutes.

I tried to use img=img[x:y , x:y], but this method crashed my python application.