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how to fill large area while thresholding

C:\fakepath\lumen-intima1.jpg

I want the image to be

C:\fakepath\lumen-intima1.jpg

how to obtain this?

how to fill large area while thresholding

~~C:\fakepath\lumen-intima1.jpg~~ $C:\fakepath\lumen-intima1.jpg$

I want the image to be

~~C:\fakepath\lumen-intima1.jpg~~ $C:\fakepath\lumen-intima1.jpg$

how to obtain this?

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