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Try :

  1. Blur image with a 13x13 window size
  2. otsu threshold
  3. use threshold image as mask to clear region

image description

Try :

  1. Blur image with a 13x13 window size
  2. otsu threshold
  3. use threshold image as mask to clear region
  4. bitwise_not of threshold image
  5. erode image (5 iterations)
  6. bitwise_and eride image and original image image description

image description