Hand micromotion recognition?

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Everything is possible. The question is: how difficult is it to realize it? And that depends on many factors. You don't provide enough informations for a good answer.

Consider following two scenarios:

scenario 1:

• always the same setting: same camera, same room, same lightning conditions, same perspective, same background, same guitar
• task: find out, if the player is playing (yes or no)

=> easy (basically a motion detector)

scenario 2:

• given: some music video clip
• task: return the song chords by detecting scenes, in which a guitar player plays chords and analyse them

=> not so easy

This video have some about this question. The author, among other things, addresses micromovements on the guitar strings. - https://www.youtube.com/watch?v=ONZcjs1Pjmk

The complete work you will find here: - http://people.csail.mit.edu/mrub/vidmag/