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You have several questions:

1. To detect hand gestures there are several approaches, from cascade classifiers, to shape based analysis. Try to define which technique you want to use first.
2. You can use OpenCV and its OpenNI interface to detect the hands in 3D depth info images, BUT if you want to do more than that, move to PCL.
3. PCL is not build by OpenCV, in fact it is a complete different library. PCL focusses on 3D point cloud operations and OpenCV (mainly) on 2D computer vision operations. However PCL does need a working OpenCV installation to work.

You have several questions:questions, here are some answers:

1. To detect hand gestures there are several approaches, from cascade classifiers, to shape based analysis. Try to define which technique you want to use first.
2. You can use OpenCV and its OpenNI interface to detect the hands in 3D depth info images, BUT if you want to do more than that, move to PCL.
3. PCL is not build by OpenCV, in fact it is a complete different library. PCL focusses on 3D point cloud operations and OpenCV (mainly) on 2D computer vision operations. However PCL does need a working OpenCV installation to work.