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cv::Matchtemplate could be a start. It slides a reference image over a image and compares them at each position.

cv::Matchtemplate could be a start. It slides a reference image over a image and compares them at each position. But it could be hard to get that in realtime (maybe after downscaling your desktop image or moving it to a GPU).

Next option would be feature based (Sift, Surf, ORB,...).

Do you have a perfect match? (e.g. are you looking for a specific icon?)